Author

G. F. Tibbits

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 5 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

R. J. Solaro· 3 shared S. Lindert· 3 shared A. Y. LI· 2 shared F. Jayousi· 2 shared H. Hamledari· 2 shared K. Rayani· 2 shared R. Nagalingam· 2 shared S. Dababneh· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

R. J. Solaro

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Molecular and metabolomic characterization of hiPSC-derived cardiac fibroblasts transitioning to myofibroblasts

R. Nagalingam, F. Jayousi, H. Hamledari, D. Hosseini, S. Dababneh, C. Lindsay, R. Klein Geltink, P. Lange, I. M. C. Dixon, R. A. Rose, M. P. Czubryt, G. F. Tibbits

This study shows that passaging hiPSC-derived cardiac fibroblasts activates them to myofibroblasts, involving TGFβ1, Hippo signaling, and mitochondrial metabolism changes.

bioRxiv · Oct 8, 2023Cell Biology

Mechanisms of Pathogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant R278C+/- During Development

S. Shafaattalab, A. Y. LI, Y. Maaref, F. Jayousi, S. Dababneh, H. Hamledari, D. H. Baygi, T. Barszczewski, B. Rupai, S. Jannati, R. Nagalingam, A. M. Cool, P. Langa, M. Chiao, T. Roston, , G. F. Tibbits

This study investigates the pathogenic mechanisms of the TNNT2 R278C+/- variant in cardiomyocytes using proteomics and functional assays, revealing its impact on cardiac function and arrhythmia.

bioRxiv · Jun 6, 2023 · PreprintCell Biology

Patient and cell-type specific hiPSC-modeling of a truncating titin variant associated with atrial fibrillation

K. Huang, M. Ashraf, L. Rohani, Y. Luo, A. Sacayanan, H. Huang, A. Haegert, S. Volik, F. Sar, S. LeBihan, J. Liew, J. D. Roberts, G. F. Tibbits, J. M. Churko, S. Sanatani, , Z. W. Laksman

This study uses patient-derived iPSC-CMs to show that a titin truncating variant increases arrhythmia susceptibility and disrupts sarcomere structure in both atrial and ventricular tissues.

bioRxiv · Mar 2, 2023 · PreprintCell Biology

The effect of magnesium on calcium binding to cardiac troponin C related hypertrophic cardiomyopathy mutants

K. Rayani, E. Hantz, O. Haji-Ghassemi, A. Y. Li, A. M. Spuches, F. Van Petegem, R. J. Solaro, S. Lindert, G. F. Tibbits

This study investigates how magnesium affects calcium binding to cardiac troponin C mutants linked to hypertrophic cardiomyopathy, showing that Mg2+ competes with Ca2+ and modifies binding affinity.

bioRxiv · May 12, 2021 · PreprintCell Biology

Drug Screening Platform Using Human Induced Pluripotent Stem Cell-Derived Atrial Cardiomyocytes and Optical Mapping

M. Gunawan, S. Sangha, S. Shafaattalab, E. Lin, D. Heims-Waldron, V. Bezzerides, Z. Laksman, G. F. Tibbits

This study develops a drug screening platform using human iPSC-derived atrial cardiomyocytes and optical mapping to evaluate atrial-selective compounds.

bioRxiv · Jul 14, 2020Pharmacology & Toxicology

Binding of Calcium and Magnesium to Cardiac Troponin C

K. Rayani, J. T. Seffernick, Y. A. Li, J. P. Davis, A. Spuches, F. V. Petegem, R. J. Solaro, S. Lindert, G. F. Tibbits

This study quantifies Ca2+/Mg2+ binding to cardiac troponin C site II, showing Mg2+ can occupy site II and reduce Ca2+ affinity at physiological concentrations.

bioRxiv · Jun 14, 2020 · PreprintCell Biology