J. Truksa

Selective killing of cancer cells via simultaneous destabilization of mitochondrial iron metabolism and induction of ferroptosis elicited by mitochondrially targeted iron chelator deferasirox

This study introduces mitoDFX, a mitochondrially targeted iron chelator that simultaneously depletes iron and induces ferroptosis, showing high selectivity and efficacy against cancer cells.

Preparation of single-cell suspension from mouse breast cancer focusing on preservation of original cell state information and cell type composition

This study optimizes single-cell dissociation protocols for mouse breast cancer tissue to preserve cell state and composition, using RT-qPCR and scRNA-seq validation.