J. Stursa

Selective killing of cancer cells via simultaneous destabilization of mitochondrial iron metabolism and induction of ferroptosis elicited by mitochondrially targeted iron chelator deferasirox

This study introduces mitoDFX, a mitochondrially targeted iron chelator that simultaneously depletes iron and induces ferroptosis, showing high selectivity and efficacy against cancer cells.

Repurposing of mitochondria-targeted tamoxifen: Novel anti-cancer drug exhibits potent activity against major protozoan and fungal pathogens.

This paper demonstrates that MitoTam, a mitochondria-targeted tamoxifen analog, effectively kills various pathogens including fungi, Plasmodium falciparum, and trypanosomatid parasites in vitro and in vivo.