R. Sedlacek

Selective killing of cancer cells via simultaneous destabilization of mitochondrial iron metabolism and induction of ferroptosis elicited by mitochondrially targeted iron chelator deferasirox

This study introduces mitoDFX, a mitochondrially targeted iron chelator that simultaneously depletes iron and induces ferroptosis, showing high selectivity and efficacy against cancer cells.

ABIN1 is a negative regulator of effector functions in cytotoxic T cells

This study identifies ABIN1 as a negative regulator of effector functions in cytotoxic T cells, showing its role in suppressing NF-κB and p38 pathways.

Aberrant activation of the innate immune sensor PKR by self dsRNA is prevented by direct interaction with ADAR1

The paper identifies PKR as a second dsRNA sensor aberrantly activated in Adar mutant mice and shows ADAR1 directly inhibits PKR through dsRNA-binding.

Human neutralizing antibodies to cold linear epitopes and to subdomain 1 of SARS-CoV-2

The paper identifies broadly cross-reactive neutralizing antibodies against SARS-CoV-2 variants using coldspot-guided antibody discovery.

A mixture of innate cryoprotectants is key for freeze tolerance and cryopreservation of a drosophilid fly larva.

The paper identifies and quantifies cryoprotectants in a freeze-tolerant fly larva and shows their synergistic effects in cryopreservation.

LAMP3 is critical for surfactant homeostasis in mice

This study shows that LAMP3 is essential for maintaining pulmonary surfactant homeostasis in mice, as its absence leads to altered surfactant composition and lung function.

DDI2 protease activity controls embryonic development and inflammation via TCF11/NRF1

This study shows that DDI2 protease is essential for embryonic development and immune balance by regulating TCF11/NRF1 and proteostasis.

Cytotoxicity of the effector protein BteA was attenuated in Bordetella pertussis by insertion of an alanine residue

This paper identifies an alanine insertion at position 503 in B. pertussis BteA that reduces its cytotoxicity compared to B. bronchiseptica BteA, contributing to attenuated virulence and immune response.

Deubiquitylase UCHL3 drives error correction at kinetochores and chromosome segregation independent of spindle assembly checkpoint

Regulation of neutrophil NADPH oxidase by PSTPIP2 affects bone damage in murine autoinflammatory osteomyelitis

This study shows that PSTPIP2 regulates neutrophil NADPH oxidase, and its loss leads to increased ROS production and bone damage in a murine model of autoinflammatory osteomyelitis.