Confinement of unliganded EGFR by tetraspanin nanodomains gates EGFR ligand binding and signaling
M. G. Sugiyama, A. I. Brown, J. Vega-Lugo, A. M. Scott, K. Jaqaman, G. D. Fairn, C. N. Antonescu
This study shows that EGFR confinement in tetraspanin nanodomains regulates ligand binding and signaling by preferentially facilitating ligand binding in these domains.
bioRxiv · Mar 4, 2022Cell Biology