G. D. Fairn

Attenuating ABHD17 isoforms augments the S-acylation and function of NOD2 and a subset of Crohns disease-associated NOD2 variants.

This study identifies ABHD17 isoforms as deacylases of NOD2, showing that inhibiting them enhances NOD2 membrane localization and function in Crohn's disease-associated variants.

Fatty Acid Synthase inhibitor TVB-3166 prevents S-acylation of the Spike protein of human coronaviruses.

This study shows that TVB-3166 inhibits S-acylation of coronavirus Spike proteins, reducing viral spread and improving survival in mice.

Apolipoprotein A1 and high-density lipoprotein limit low-density lipoprotein transcytosis by binding scavenger receptor B1

This study shows that APOA1 and HDL reduce LDL transcytosis by competing with LDL for SR-B1 binding, thereby limiting atherosclerosis.

HER2 expression defines unique requirements for flotillin and c-Src for EGFR signaling

The paper shows HER2 expression uniquely requires flotillin and c-Src for EGFR signaling and Akt activation in membrane rafts.

PtdIns(3,4)P2, Lamellipodin, and VASP coordinate cytoskeletal remodeling during phagocytic cup formation in macrophages.

Confinement of unliganded EGFR by tetraspanin nanodomains gates EGFR ligand binding and signaling

This study shows that EGFR confinement in tetraspanin nanodomains regulates ligand binding and signaling by preferentially facilitating ligand binding in these domains.

Anisotropy of plasmalemmal sterols and cell mating require StARkin domain proteins Ysp2 and Lam4.

The paper shows that Ysp2 and Lam4 proteins regulate ergosterol distribution in yeast, affecting cell polarity and mating.

Phosphatidylinositol 3-kinase-independent synthesis of PtdIns(3,4)P2 by a phosphotransferase

The paper shows that Salmonella and Shigella effectors generate PtdIns(3,4)P2 independently of phosphoinositide 3-kinases using a phosphotransferase mechanism.

Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease