K. Jaqaman

Multiscale imaging and quantitative analysis of plasma membrane protein-cortical actin interplay

This paper develops a multiscale imaging framework to study the relationship between cortical actin and plasma membrane protein organization, revealing differential interactions based on protein properties and local actin environment.

Confinement of unliganded EGFR by tetraspanin nanodomains gates EGFR ligand binding and signaling

This study shows that EGFR confinement in tetraspanin nanodomains regulates ligand binding and signaling by preferentially facilitating ligand binding in these domains.

Analysis of conditional colocalization relationships and hierarchies from three-color microscopy images

The paper introduces a method to analyze conditional colocalization in three-color microscopy images and demonstrates its application to study molecular compartmentalization and interaction hierarchies.

Computational analysis of lamin isoform interactions with nuclear pore complexes

The paper analyzes lamin isoform interactions with nuclear pore complexes using microscopy data from mouse fibroblasts, showing their role in maintaining nuclear envelope organization.

Heterogeneity in VEGF Receptor-2 mobility and organization on the endothelial cell surface leads to diverse activation models by VEGF

This study examines VEGFR-2 mobility and organization on endothelial cells, revealing how receptor heterogeneity influences VEGF activation mechanisms.

FISIK: Framework for the Inference of in Situ Interaction Kinetics from single-molecule imaging data

FISIK infers molecular interaction kinetics from single-molecule imaging data by modeling molecular movement and interactions, and estimating kinetic rates through parameter fitting.

A Composition-Dependent Molecular Clutch Between T Cell Signaling Clusters and Actin

The paper investigates how Nck and WASP mediate the movement of LAT condensates across actin networks during T cell activation.