Author

J. W. Harbour

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

, Y. Sayegh· 1 shared A. M. Bowcock· 1 shared A. Polo· 1 shared C. Decatur· 1 shared D. Hinds· 1 shared D. McCracken· 1 shared D. Pelaez· 1 shared E. J. Kennedy· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

, Y. Sayegh

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2 papers

Recent·Most cited

RB1 loss triggers dependence on ESRRG in retinoblastoma

M. G. Field, J. N. Kuznetsoff, M. Zhang, J. J. Dollar, M. A. Durante, , Y. Sayegh, C. Decatur, S. Kurtenbach, D. Pelaez, J. W. Harbour

This study identifies ESRRG as a novel dependency in retinoblastoma cells following RB1 loss, showing its role in retinogenesis and oxygen metabolism and suggesting it as a therapeutic target.

bioRxiv · Dec 15, 2021Cancer Biology

Kinetics characterization of ASXL1/2-mediated allosteric regulation of BAP1 deubiquitinase

H. Peng, J. Cassel, D. McCracken, J. W. Prokop, P. R. Collop, A. Polo, S. Joshi, J. P. Mandell, K. Ayyanathan, D. Hinds, S. B. Malkowicz, J. W. Harbour, A. M. Bowcock, J. Salvino, E. J. Kennedy, , F. J. Rauscher

This study characterizes the kinetics and stoichiometry of BAP1 and ASXL2 interactions, revealing their structural and functional properties in deubiquitinase activity.

bioRxiv · Feb 24, 2020Cancer Biology