Differential requirements for mitochondrial electron transport chain components in the adult murine liver
N. P. Lesner, X. Wang, Z. Chen, A. Frank, C. Menezes, S. House, S. D. Shelton, D. G. McFadden, J. Wansapura, R. J. DeBerardinis, P. Mishra
This study investigates the tissue-specific roles of mitochondrial complex I and IV in adult mouse liver, finding that complex I loss is tolerated while complex IV dysfunction causes metabolic and functional impairments.
bioRxiv · Jul 15, 2021Cell Biology