Author

A. Chandran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:metagenomics· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

B. Chain· 2 shared J. Rosenheim· 2 shared M. Noursadeghi· 2 shared A. Beck· 1 shared A. Camara· 1 shared A. J. Mentzer· 1 shared A. Koller· 1 shared A. Matson· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

B. Chain

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Single-cell transcriptome and T cell receptor profiling of the tuberculin skin test

C. T. Turner, J. Rosenheim, C. Thakker, A. Chandran, H. Wilson, C. Venturini, G. Pollara, B. Chain, G. S. Tomlinson, M. Noursadeghi

The paper profiles single-cell transcriptomes and T cell receptors in human tuberculin skin tests to characterize the immune response to Mycobacterium tuberculosis.

bioRxiv · Jun 25, 2024 · PreprintImmunology

Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection.

M. Milighetti, Y. Peng, C. C. S. Tan, M. Mark, G. Nageswaran, S. Byrne, T. Ronel, T. Peacock, A. Mayer, A. Chandran, J. Rosenheim, M. Wheelan, X. Yao, G. Liu, S. L. Felce, , B. Chain

The paper identifies high frequency naive T cell precursors that drive rapid T cell responses during early SARS-COV-2 and LCMV infections.

bioRxiv · Nov 8, 2022Immunology

A simple, cost-effective and automation-friendly direct PCR approach for bacterial community analysis

F. Song, J. V. Kuehl, A. Chandran, A. P. Arkin

This paper introduces a direct PCR method for bacterial community analysis that is cheaper, faster, and more scalable than traditional DNA extraction methods.

bioRxiv · Mar 1, 2021Microbiology

Proposed model of the Dictyostelium cAMP receptors bound to cAMP

J. C. Greenhalgh, A. Chandran, M. T. Harper, G. Ladds, T. Rahman

The paper presents homology models of cAMP receptors from Dictyostelium discoideum, highlighting structural features that may explain differential cAMP binding affinities and activation mechanisms.

bioRxiv · Jan 3, 2020Biochemistry

Targeting the Pregnane X Receptor Using Microbial Metabolite Mimicry

Z. Dvorak, F. Felix Kopp, C. M. Costello, J. S. Kemp, H. Li, A. Vrzalova, M. Stepankova, I. Iveta Bartonkov, K. Poulikova, B. Vyhlidalova, L. U. Nordstroem, C. Karunaratne, H. Ranhotra, K. S. Mun, A. P. Naren, , R. B. Sartor

This paper develops FKK6, a non-cytotoxic PXR agonist derived from microbial metabolite mimicry, which reduces inflammation and validates the strategy for drug discovery.

bioRxiv · Jan 3, 2020Biochemistry

Alpha-Synuclein is a Target of Fic-mediated Adenylylation/AMPylation: Implications for Parkinson’s Disease

S. Mattoo, A. Sanyal, S. Dutta, A. Chandran, A. Koller, A. Camara, B. G. Watson, R. Sengupta, D. Ysselstein, P. Montenegro, J. R. Cannon, C. Rochet

The paper identifies alpha-Synuclein as a target of HYPE-mediated adenylylation, showing it reduces Syn aggregation and ER stress in Parkinson’s disease models.

bioRxiv · Jan 21, 2019Biochemistry