R. B. Sartor

Mouse Adaptation of Human Inflammatory Bowel Diseases Microbiota Enhances Colonization Efficiency and Alters Microbiome Aggressiveness Depending on Recipient Colonic Inflammatory Environment

This study shows that adapting human IBD microbiota for mice improves colonization efficiency and alters microbiome aggressiveness based on the recipient's inflammatory environment.

Protective and aggressive bacterial subsets and metabolites modify hepatobiliary inflammation and fibrosis in PSC.

This study identifies protective and aggressive bacterial subsets and metabolites in PSC patients and mice, showing their impact on hepatobiliary inflammation and fibrosis.

BET protein inhibition regulates macrophage chromatin accessibility and microbiota-dependent colitis

This study shows that BET protein inhibition reduces macrophage inflammation and colitis severity by altering chromatin accessibility and gene expression.

Targeting the Pregnane X Receptor Using Microbial Metabolite Mimicry

This paper develops FKK6, a non-cytotoxic PXR agonist derived from microbial metabolite mimicry, which reduces inflammation and validates the strategy for drug discovery.

Yersiniabactin producing AIEC promote inflammation-associated fibrosis in gnotobiotic Il10-/- mice

The paper shows that Yersiniabactin-producing AIEC bacteria cause inflammation-associated fibrosis in mice, with Ybt import receptor FyuA influencing fibrosis severity.