Resistance profiling of Aspergillus fumigatus to olorofim indicates absence of intrinsic resistance and unveils the molecular mechanisms of acquired olorofim resistance
J. B. Buil, J. D. Oliver, D. Law, T. J. H. Baltussen, J. Zoll, M. Hokken, M. C. Tehupeiory-Kooreman, W. J. G. Melchers, M. Birch, P. E. Verweij
This study shows no intrinsic resistance to olorofim in A. fumigatus but identifies acquired resistance through PyrE gene mutations, with some fitness costs.
bioRxiv · Nov 16, 2021Microbiology