Author

T. C. T. Lan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metagenomics· 1

Frequent Co-Authors

S. Rouskin· 2 shared A. G. Sanderlin· 1 shared A. Griffiths· 1 shared A. L. Herneisen· 1 shared B. S. Waldman· 1 shared C. J. Giuliano· 1 shared D. M. McCormick· 1 shared E. A. Boydston· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMicrobiology

S. Rouskin

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Functional profiling of the Toxoplasma genome during acute mouse infection

C. J. Giuliano, K. J. Wei, F. M. Harling, B. S. Waldman, M. A. Farringer, E. A. Boydston, T. C. T. Lan, R. W. Thomas, A. L. Herneisen, A. G. Sanderlin, I. Coppens, J. D. Dvorin, S. Lourido

The paper uses CRISPR screens to identify 300+ genes in Toxoplasma gondii that affect parasite fitness in mice, revealing new roles in host-parasite interactions and potential drug targets.

bioRxiv · Mar 5, 2023 · PreprintMicrobiology

Translational activation by an alternative sigma factor in Bacillus subtilis

D. M. McCormick, J.-B. Lalanne, T. C. T. Lan, S. Rouskin, G.-W. Li

The paper shows that the sigma factor σB in Bacillus subtilis induces translation of its regulon genes by relieving RNA secondary structures, leading to significant translation efficiency differences compared to σA.

bioRxiv · Mar 6, 2021Microbiology

Insights into the secondary structural ensembles of the full SARS-CoV-2 RNA genome in infected cells

T. C. T. Lan, M. F. Allan, L. Malsick, S. Khandwala, S. S. Y. Nyeo, Y. Sun, J. U. Guo, M. Bathe, A. Griffiths, S. Rouskin

This study identifies RNA secondary structures of the full SARS-CoV-2 genome in infected cells, revealing alternative conformations that influence frameshifting rates.

bioRxiv · Jun 29, 2020Biochemistry