Author

J.-S. Silvestre

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

A. Zernecke· 2 shared A.-E. Saliba· 2 shared C. Cochain· 2 shared E. Vafadarnejad· 2 shared G. Rizzo· 2 shared J. VILAR· 2 shared P. Alayrac· 2 shared P. Arampatzi· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersImmunology

A. Zernecke

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

EphrinA4/EphA4 controls blood pressure via arterial sympathetic innervation

E. SIMONNET, S. MARTIN, J. VILAR, E. ROY-VESSIERES, S. TAIB, V. MONCEAU, L. Pardanaud, N. BOUBY, A. Eichmann, J.-S. SILVESTRE, D. HENRION, I. V. BRUNET

This study shows EphrinA4 in arterial SMCs repels sympathetic axons, and its loss increases sympathetic innervation, leading to elevated blood pressure and hypertension under stress.

bioRxiv · Feb 3, 2023 · PreprintPhysiology

Inhibition of integrin alpha V (CD51) reduces inflammation and transition to heart failure following pressure overload

C. Delacroix, A. Achab-Ali, P. Alayrac, M. Gandon-Renard, F. Drame, D. A. Sassoon, J.-S. Silvestre, J.-S. Hulot

This study shows that inhibiting integrin alpha V reduces inflammation and prevents heart failure progression in pressure-overloaded mice by modulating pro-inflammatory macrophages.

bioRxiv · Oct 10, 2022 · PreprintPharmacology & Toxicology

Time-resolved single-cell transcriptomics uncovers dynamics of cardiac neutrophil diversity in murine myocardial infarction

E. Vafadarnejad, G. Rizzo, L. Krampert, P. Arampatzi, V. A. Nugroho, D. J. Schulz, M. Roesch, P. Alayrac, J. Vilar, J.-S. Silvestre, A. Zernecke, A.-E. Saliba, C. Cochain

This study uses time-resolved single-cell transcriptomics to analyze cardiac neutrophil diversity in murine myocardial infarction, identifying distinct subsets and their temporal dynamics.

Circulation Research · Oct 9, 2020Peer-reviewedImmunology

Single-cell transcriptomic profiling maps monocyte/macrophage transitions after myocardial infarction in mice

G. Rizzo, E. Vafadarnejad, P. Arampatzi, J.-S. Silvestre, A. Zernecke, A.-E. Saliba, C. Cochain

This study maps monocyte/macrophage transitions after myocardial infarction in mice using single-cell transcriptomics, identifying key transcriptional states and regulators.

bioRxiv · Apr 14, 2020Immunology