A.-E. Saliba

Neural Network-Assisted Humanization of COVID-19 Hamster scRNAseq Data Reveals Matching Severity States in Human Disease

This paper uses neural networks to match disease states between human and hamster COVID-19 scRNAseq data, finding similar cellular responses in specific cell types across species.

A novel in vitro tubular model to recapitulate features of distal airways: The bronchioid

The paper introduces a bronchioid model using human bronchial stem cells in an alginate scaffold to mimic distal airway structure and function, showing ciliary activity and pathophysiological features.

Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response

The paper investigates interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammation, showing increased proximity and functional effects in COPD patients.

Rapid differentiation of regulatory CD4+ T cells in the infarcted myocardium blunts in situ inflammation

This study shows that CD4+ T cells in the infarcted heart rapidly become regulatory, reducing inflammation, and identifies mechanisms of their differentiation and function.

Non-productive exposure of PBMCs to SARS-CoV-2 induces cell-intrinsic innate immunity responses

The paper shows that non-productive exposure of PBMCs to SARS-CoV-2 triggers JAK/STAT-dependent innate immune responses in monocytes, similar to those seen in mild COVID-19.

Postnatal lymph node expansion of stromal progenitors towards reticular and CD34+ stromal cell subsets is determined by distinct transcriptional programs

The paper identifies distinct transcriptional programs driving the expansion of stromal progenitors in mesenteric lymph nodes, revealing Irf3's role in FRC differentiation and microbiota-independent epigenomic signatures.

Vector-borne Trypanosoma brucei parasites develop in artificial human skin and persist as skin tissue forms

This study tracks Trypanosoma brucei development in artificial human skin, identifying a quiescent state called skin tissue forms that may sustain infection.

Initial HCV infection of adult hepatocytes triggers a temporally structured transcriptional program containing diverse pro- and anti-viral elements

This study identifies temporally structured transcriptional changes in HCV-infected human hepatocytes, revealing both antiviral and pro-viral programs that may contribute to viral persistence.

Integrated scRNA-seq analysis identifies conserved transcriptomic features of mononuclear phagocytes in mouse and human atherosclerosis

This study integrates scRNA-seq data from mouse and human atherosclerosis to identify conserved transcriptomic features of mononuclear phagocytes across species.

Single-cell transcriptomic profiling maps monocyte/macrophage transitions after myocardial infarction in mice

This study maps monocyte/macrophage transitions after myocardial infarction in mice using single-cell transcriptomics, identifying key transcriptional states and regulators.

Time-resolved single-cell transcriptomics uncovers dynamics of cardiac neutrophil diversity in murine myocardial infarction

This study uses time-resolved single-cell transcriptomics to analyze cardiac neutrophil diversity in murine myocardial infarction, identifying distinct subsets and their temporal dynamics.