Exploration of Mechanisms of Drug Resistance in a Microfluidic Device and Patient Tissues
W. Lim, I. Hwang, J. Zhang, Z. Chen, J. Han, J. Jeon, B.-K. Koo, S. Kim, J. E. Lee, Y. Kim, K. J. Pienta, S. R. Amend, R. H. Austin, J.-Y. Ahn, S. Park
This study uses a microfluidic device to induce drug resistance in TNBC cells and identifies the NUPR1/HDAC11 axis as a key factor in chemoresistance, correlating high Nupr1 expression with poor clinical outcomes.
bioRxiv · Nov 14, 2022 · PreprintCancer Biology