Author

I. Hwang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Plant Biology· 5 Cancer Biology· 4 Cell Biology· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Organism:Arabidopsis· 5 Research Focus:cell type annotation· 5 Research Focus:chromatin & epigenetic regulation· 5 Assay:bulk RNA-seq· 4 Research Focus:cell signaling & trafficking· 4 Organism:human· 4 Organism:mouse· 4

Frequent Co-Authors

H. Zheng· 4 shared J. Paik· 4 shared J. Yao· 3 shared C. Kim· 2 shared D. Byun· 2 shared E.-J. Kim· 2 shared F. Li· 2 shared G. De Jaeger· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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4 shared papersCancer Biology

H. Zheng

Mutual co-authors in cluster

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14 papers

Recent·Most cited

Decoding spatial organization maps and context-specific landscapes of breast cancer and its microenvironment via high-resolution spatial transcriptomic analysis

E. S. Seo, B. Lee, I. Hwang, J.-Y. Kim, K. Park, W.-Y. Park

This study uses high-resolution spatial transcriptomics to analyze breast cancer and its microenvironment, revealing spatially distinct immune cell gradients and transcriptional differences between tumors.

bioRxiv · Oct 25, 2023 · PreprintCancer Biology

Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance

F. Li, Y. Wang, I. Hwang, J.-Y. Janng, L. Zhou, Z. Deng, E. Y. Yu, Y. Cai, C. Wu, Z. Han, Y.-H. Huang, X. Huang, L. Zhang, J. Yao, N. Lue, , H. Zheng

The paper identifies KDM2A as a selective vulnerability in ALT-dependent cancers by showing its role in telomere cluster dissolution through SENP6-mediated SUMO deconjugation.

bioRxiv · Feb 10, 2023 · PreprintCancer Biology

SnRK1 inhibits anthocyanin biosynthesis through both transcriptional regulation and direct phosphorylation and dissociation of the MYB/bHLH/TTG1 MBW complex.

E. Broucke, T. V. T. Dang, Y. Li, S. Hulsmans, J. Van Leene, G. De Jaeger, I. Hwang, W. Van den Ende, F. A. Rolland

This study shows that SnRK1 represses anthocyanin biosynthesis by inhibiting the MBW complex transcriptionally and through direct phosphorylation and dissociation of its components.

bioRxiv · Nov 21, 2022Plant Biology

Exploration of Mechanisms of Drug Resistance in a Microfluidic Device and Patient Tissues

W. Lim, I. Hwang, J. Zhang, Z. Chen, J. Han, J. Jeon, B.-K. Koo, S. Kim, J. E. Lee, Y. Kim, K. J. Pienta, S. R. Amend, R. H. Austin, J.-Y. Ahn, S. Park

This study uses a microfluidic device to induce drug resistance in TNBC cells and identifies the NUPR1/HDAC11 axis as a key factor in chemoresistance, correlating high Nupr1 expression with poor clinical outcomes.

bioRxiv · Nov 14, 2022 · PreprintCancer Biology

Water wisteria genome reveals environmental adaptation and heterophylly regulation in amphibious plants

G. Li, X. Zhao, J. Yang, S. Hu, J. Ponnu, S. Kimura, I. Hwang, K. U. Torii, H. Hou

This study sequenced the genome of water wisteria, revealing genes and pathways involved in its environmental adaptation and leaf shape changes.

bioRxiv · Sep 19, 2022Plant Biology

SARS-CoV-2 Infection of Microglia Elicits Pro-inflammatory Activation and Apoptotic Cell Death

G. U. Jeong, J. Lyu, K.-D. Kim, Y. C. Chung, G. Y. Yoon, S. Lee, I. Hwang, W.-H. Shin, J. Ko, J.-Y. Lee, Y.-C. Kwon

This paper shows SARS-CoV-2 directly infects human microglia, causing pro-inflammatory activation and apoptosis, which may contribute to neurological issues in COVID-19 patients.

bioRxiv · Jan 4, 2022 · PreprintMicrobiology

Comparison of Plaque Size, Thermal Stability, and Replication Rate among SARS-CoV-2 Variants of Concern

G. U. Jeong, G. Y. Yoon, H. W. Moon, W. Lee, I. Hwang, H. S. Kim, K.-D. Kim, C. Kim, D.-G. Ahn, B.-T. Kim, S.-J. Kim, Y.-C. Kwon

This study compares plaque size, thermal stability, and replication rates of four SARS-CoV-2 variants of concern and finds differences in these characteristics among them.

Viruses · Dec 30, 2021Peer-reviewedMicrobiology

HEAT SHOCK FACTOR BINDING PROTEIN limits meiotic crossovers by repressing HEI10 transcription

J. Kim, J. Park, H. Kim, N. Son, C. Lambing, E.-J. Kim, J. Kim, D. Byun, Y. Lee, Y. M. Park, D. C. Nageswaran, P. Kuo, T. V. T. Dang, I. Hwang, I. R. Henderson, K. Choi

This study identifies HSBP as a repressor of HEI10 transcription and meiotic crossovers in Arabidopsis by binding to HSFs and maintaining DNA methylation at the HEI10 promoter.

bioRxiv · Oct 17, 2021Plant Biology

Proteomic Characterization of Isolated Arabidopsis Clathrin-Coated Vesicles Reveals Evolutionarily Conserved and Plant Specific Components

D. A. Dahhan, G. D. Reynolds, J. J. Cardenas, D. Eeckhout, A. Johnson, K. Yperman, W. Kaufmann, N. Vang, X. Yan, I. Hwang, A. Heese, G. De Jaeger, J. Friml, D. Van Damme, J. Pan, S. Y. Bednarek

The paper characterizes the proteome of Arabidopsis clathrin-coated vesicles, identifying conserved and plant-specific components involved in clathrin-mediated trafficking.

bioRxiv · Sep 16, 2021Cell Biology

TIC236 gain-of-function mutations unveil the link between plastid division and plastid protein import

C. Kim, J. Fang, B. Li, L.-J. Chen, V. Dogra, S. Luo, P. Wang, I. Hwang, H.-m. Li

This study identifies TIC236 gain-of-function mutations that enhance plastid protein import and reveal their role in plastid division and plant stress response.

bioRxiv · Apr 25, 2021Plant Biology

Therapy-induced transdifferentiation promotes glioma growth independent of EGFR signaling

H. Oh, I. Hwang, L. Wu, D. Cao, J. Yao, H. Ying, J. Y. Li, Y. Yao, B. Hu, Q. Wang, H. Zheng, J. Paik

This study identifies therapy-induced transdifferentiation as a mechanism of EGFR-targeted therapy resistance in gliomas, independent of EGFR signaling, and suggests combinatorial therapies targeting both EGFR and transdifferentiation pathways.

bioRxiv · Jun 2, 2020Cancer Biology

Cellular Stress Signaling Activates Type-I IFN Response Through FOXO3-regulated Lamin Posttranslational Modification

I. Hwang, Z. Dai, F. Li, T. Sanchez, J. W. Locasale, L. L. Cantley, H. Zheng, J. Paik

The paper shows that oxidative stress in NSPCs activates the IFN-I response via FOXO3-regulated lamin modifications, preserving their regenerative potential.

bioRxiv · May 3, 2020Cell Biology

CIC is a Critical Regulator of Neuronal Differentiation

I. Hwang, H. Pan, J. Yao, O. Elemento, H. Zheng, J. Paik

This study identifies CIC as a critical regulator of neuronal differentiation by repressing VGF expression through a corepressor complex, linking its dysfunction to brain tumor development.

bioRxiv · Oct 9, 2019Cell Biology

DeepTetrad: high-throughput analysis of meiotic tetrads by deep learning in plants

E.-C. Lim, J. Kim, J. Park, E.-J. Kim, J. Kim, H. S. Cho, D. Byun, I. R. Henderson, G. P. Copenhaver, I. Hwang, K. Choi

DeepTetrad uses deep learning to analyze pollen tetrads and measure crossover frequency and interference in Arabidopsis plants.

bioRxiv · Jun 21, 2019Plant Biology