Author

B.-K. Koo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 6 Organism:human· 6 Research Focus:differential expression· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Research Focus:gene regulatory network inference· 3

Frequent Co-Authors

J. Kim· 3 shared J.-H. Lee· 3 shared A. Merenda· 2 shared H. Lee· 2 shared I. Jordens· 2 shared J. Choi· 2 shared M. M. Maurice· 2 shared T. Radaszkiewicz· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersCell Biology

J. Kim

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Acquired epithelial WNT secretion drives niche independence of developing gastric cancer

I. Teriyapirom, J. Kim, H. Lee, S. R. Merker, A. Andersson-Rolf, S. R. Jahn, A.-M. Ada, S.-M. Kim, J. Y. Lim, T. Schmaeche, N. Wetterling, S. Stegert, J.-Y. Park, J.-H. Cheong, H. Kim, , B.-K. Koo

The paper identifies WNT2B and WNT7B as key ligands maintaining gastric epithelium homeostasis and shows that gastric cancer gains WNT independence through epithelial secretion of WNT7B via MAPK activation.

bioRxiv · Feb 24, 2023 · PreprintCancer Biology

Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2

G. Colozza, H. Lee, A. Merenda, S.-H. Wu, A. Catala-Bordes, T. Radaszkiewicz, I. Jordens, J.-H. Lee, A.-D. Bamford, F. Farnhammer, T. Y. Low, M. M. Maurice, V. Bryja, J. Kim, B.-K. Koo

This study identifies Daam1/2 as a regulator of Wnt signaling that is essential for Paneth cell differentiation and intestinal stem cell homeostasis.

bioRxiv · Jan 24, 2023Cell Biology

Exploration of Mechanisms of Drug Resistance in a Microfluidic Device and Patient Tissues

W. Lim, I. Hwang, J. Zhang, Z. Chen, J. Han, J. Jeon, B.-K. Koo, S. Kim, J. E. Lee, Y. Kim, K. J. Pienta, S. R. Amend, R. H. Austin, J.-Y. Ahn, S. Park

This study uses a microfluidic device to induce drug resistance in TNBC cells and identifies the NUPR1/HDAC11 axis as a key factor in chemoresistance, correlating high Nupr1 expression with poor clinical outcomes.

bioRxiv · Nov 14, 2022 · PreprintCancer Biology

Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration

J. Choi, Y. J. Jang, C. Dabrowska, E. Iich, K. Evans, H. Hall, S. M. Janes, B. D. Simons, B.-K. Koo, J. Kim, J.-H. Lee

The paper identifies an IL-1β-Notch-Fosl2 axis that regulates differentiation plasticity of airway progenitors during alveolar regeneration.

bioRxiv · Jun 19, 2021Cell Biology

Loss of RNF43/ZNRF3 predisposes to Hepatocellular carcinoma by impairing liver regeneration and altering liver fat metabolism

G. Mastrogiovanni, C. Pacini, S. Kakava, R. Arnes-Benito, C. R. Bradshaw, S. Davies, K. Saeb-Parsy, B.-K. Koo, M. Huch

This study shows that loss of RNF43/ZNRF3 leads to liver cancer by disrupting lipid metabolism and impairing liver regeneration in mice, with similar effects observed in human patients.

bioRxiv · Sep 25, 2020 · PreprintCancer Biology

Reconstitution of Alveolar Regeneration via novel DATPs by Inflammatory Niches

J. Choi, J.-E. Park, G. Tsagkogeorga, M. Yanagita, B.-K. Koo, N. Han, J.-H. Lee

The paper identifies DATPs as a novel progenitor population in alveolar regeneration and shows how IL-1β-mediated inflammation impairs their differentiation into mature AT1 cells.

bioRxiv · Jun 14, 2020 · PreprintCell Biology

RNF43 truncating mutations mediate a tumour suppressor-to-oncogene switch to drive niche-independent self-renewal in cancer

M. Spit, N. Fenderico, I. Jordens, T. Radaszkiewicz, R. G. H. Lindeboom, J. M. Bugter, L. Ootes, M. van Osch, E. Janssen, K. E. Boonekamp, K. Hanakova, D. Potesil, Z. Zdrahal, S. F. Boj, J. P. Medema, , M. M. Maurice

This study identifies RNF43 truncating mutations that switch from tumor suppressor to oncogene, enabling niche-independent self-renewal in cancer and resistance to anti-Wnt therapy.

bioRxiv · Sep 1, 2019Cancer Biology

Norovirus replication in human intestinal epithelial cells is restricted by the interferon-induced JAK/STAT signalling pathway and RNA Polymerase II mediated transcriptional responses.

M. T. Hosmillo, Y. Chaudhry, K. Nayak, F. Sorgeloos, B.-K. Koo, A. Merenda, R. Lillestol, L. Drumright, M. Zilbauer, I. G. Goodfellow

This study shows that HuNoV replication in intestinal epithelial cells is restricted by IFN-induced transcriptional responses and that inhibiting these responses enhances viral replication.

bioRxiv · Aug 10, 2019 · PreprintMicrobiology