Author

S. R. Amend

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

K. J. Pienta· 5 shared M. M. Mallin· 2 shared A. L. Gonye· 1 shared B.-K. Koo· 1 shared C. Venditti· 1 shared C.-F. Lee· 1 shared C.-J. Kim· 1 shared G. Butler· 1 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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5 shared papersCancer Biology

K. J. Pienta

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5 papers

Recent·Most cited

Punctuational evolution is pervasive in distal site metastatic colonization

G. Butler, S. R. Amend, R. Axelrod, C. Venditti, K. J. Pienta

The paper shows that metastatic tumors exhibit more punctuational molecular evolution compared to primary tumors, indicating different evolutionary modes in cancer progression.

bioRxiv · Apr 8, 2024Cancer Biology

Multiparameter flow cytometric detection and analysis of rare cells in in vivo models of cancer metastasis

M. M. Mallin, K. J. Pienta, S. R. Amend

The paper introduces a flow cytometry method to detect and analyze rare CTCs and DTCs in cancer metastasis models, enabling the study of metastatic barriers across multiple steps in a single model system.

bioRxiv · Oct 12, 2023 · PreprintCancer Biology

Exploration of Mechanisms of Drug Resistance in a Microfluidic Device and Patient Tissues

W. Lim, I. Hwang, J. Zhang, Z. Chen, J. Han, J. Jeon, B.-K. Koo, S. Kim, J. E. Lee, Y. Kim, K. J. Pienta, S. R. Amend, R. H. Austin, J.-Y. Ahn, S. Park

This study uses a microfluidic device to induce drug resistance in TNBC cells and identifies the NUPR1/HDAC11 axis as a key factor in chemoresistance, correlating high Nupr1 expression with poor clinical outcomes.

bioRxiv · Nov 14, 2022 · PreprintCancer Biology

Nuclear morphology predicts cell survival to cisplatin chemotherapy

C.-J. Kim, A. L. Gonye, K. Truskowski, C.-F. Lee, R. Austin, K. J. Pienta, S. R. Amend

This study identifies nuclear morphology and functional characteristics associated with cancer cell survival after cisplatin chemotherapy, highlighting the role of the polyaneuploid cancer cell (PACC) state in treatment resistance.

bioRxiv · Sep 19, 2022Cancer Biology

Cells in the Polyaneuploid Cancer Cell (PACC) state have increased metastatic potential

M. M. Mallin, N. Kim, M. I. Choudhury, S. J. Lee, S. S. An, S. X. Sun, K. Konstantopoulos, K. J. Pienta, S. R. Amend

The paper identifies Polyaneuploid Cancer Cells (PACCs) as metastasis-competent cells through increased motility, elasticity, and survival in circulation.

bioRxiv · Sep 16, 2022Cancer Biology