Multi-omic analysis reveals nitric oxide dependent remodeling in classically activated macrophages and identifies negative regulation mediated by AKR1A1
Nicholas L. Arp, Uzziah S. Urquiza, Marcel Morgenstern, Jonathan H. Schrope, James A. Votava, Steven V John, Jack J Stevens, Felicia Deng, Anna Huttenlocher A, Joshua J. Coon, Jing Fan
This study uses multi-omic analysis to show NO* drives controlled remodeling in macrophages, with AKR1A1 mediating negative regulation of metabolic and functional changes during immune response.
Redox Biology · Apr 22, 2026Peer-reviewedImmunology