James A. Votava

This study uses multi-omic analysis to show NO* drives controlled remodeling in macrophages, with AKR1A1 mediating negative regulation of metabolic and functional changes during immune response.

This study uses optical metabolic imaging to show neutrophils rapidly shift to a reduced redox state upon activation, with heterogeneous responses across cells and donors.

This study shows that mature neutrophils can rapidly reactivate mitochondrial metabolism in response to stimuli, impacting their function and suggesting therapeutic potential for mitochondrial pyruvate carrier inhibitors.

This study shows that GATA1-deficient iPSC-derived neutrophils have enhanced antifungal activity against Aspergillus fumigatus, mediated by CD18 integrin.