Steven V John

Multi-omic analysis reveals nitric oxide dependent remodeling in classically activated macrophages and identifies negative regulation mediated by AKR1A1

This study uses multi-omic analysis to show NO* drives controlled remodeling in macrophages, with AKR1A1 mediating negative regulation of metabolic and functional changes during immune response.

Discovery of metabolites produced by reactions between central carbon metabolites and cysteine that mark inflammatory macrophages

The paper identifies sulfur-containing metabolites specific to inflammatory macrophages, showing they are produced from cysteine and central metabolism intermediates and are elevated in human inflammatory lesions.

The pyruvate branch point controls lymphoid cancer cell dissemination

This study identifies the pyruvate branch point as a metabolic checkpoint controlling lymphoid cancer cell migration and dissemination via mROS/HIF-1a signaling.