Nicholas L. Arp

This study uses multi-omic analysis to show NO* drives controlled remodeling in macrophages, with AKR1A1 mediating negative regulation of metabolic and functional changes during immune response.

The paper identifies sulfur-containing metabolites specific to inflammatory macrophages, showing they are produced from cysteine and central metabolism intermediates and are elevated in human inflammatory lesions.

This study shows that acetyl-CoA availability, regulated by AT-1, affects neuronal metabolism, growth, and synaptic activity in mice.

The paper introduces a method using the Orbitrap Astral mass spectrometer with DIA to rapidly analyze phosphoproteomes, detecting over 80,000 phosphorylation sites in mice.

This study identifies significant reprogramming of nucleotide metabolism in classically activated macrophages, revealing key regulatory mechanisms and functional consequences.