Opposing effects of systemic and pancreas-specific inhibition of BCKDK on pancreatic carcinogenesis
Michael Noji, Christina Demetriadou, Madelyn D. Landis, Jennifer L Pennise, Laura V. Pinheiro, Alison Jaccard, Adam G. Chatoff, Jack M. Drummond, Kevin Guo, Romie Azor, Maggie R. Robertson, Ryo Kawakami, Mariola M. Marcinkiewicz, John W. Tobias, Nathaniel W. Snyder, , Kathryn E. Wellen
This study shows that pancreas-specific BCKDK inhibition accelerates pancreatic cancer while systemic BCKDK inhibition reduces tumor formation.
bioRxiv · Jun 10, 2025 · PreprintCancer Biology