This study shows EGFR activation in cholangiocytes drives extrahepatic bile duct regeneration after injury by promoting proliferation and altering ligand-receptor dynamics.

Hepatology Communications · Oct 14, 2025Peer-reviewedPhysiology

Opposing effects of systemic and pancreas-specific inhibition of BCKDK on pancreatic carcinogenesis

Michael Noji, Christina Demetriadou, Madelyn D. Landis, Jennifer L Pennise, Laura V. Pinheiro, Alison Jaccard, Adam G. Chatoff, Jack M. Drummond, Kevin Guo, Romie Azor, Maggie R. Robertson, Ryo Kawakami, Mariola M. Marcinkiewicz, John W. Tobias, Nathaniel W. Snyder, , Kathryn E. Wellen

This study shows that pancreas-specific BCKDK inhibition accelerates pancreatic cancer while systemic BCKDK inhibition reduces tumor formation.

bioRxiv · Jun 10, 2025 · PreprintCancer Biology

FOG2 coding variant Ser657Gly is associated with Coronary Microvascular Disease through altered hypoxia-mediated gene transcription

Marie A. Guerraty, Shefali S. Verma, Y.A. Ko, Michael A. McQuillan, Donna Conlon, John W. Tobias, Michael G. Levin, William R. Haury, C. Zhang, Renae Judy, PennMedicine Biobank, Sarah A. Tishkoff, Scott M. Damrauer, Zoltan Pierre Arany, Daniel James Rader

The paper identifies a FOG2 variant associated with coronary microvascular disease and shows it alters hypoxia-mediated gene transcription and angiogenesis.

medRxiv · May 22, 2023 · PreprintGenetic & Genomic Medicine

Chromatin accessibility and histone acetylation in the regulation of competence in early development

Melody Esmaeili, Shelby A. Blythe, John W. Tobias, Kai Zhang, Jing Yang, Peter S. Klein

The paper investigates how chromatin accessibility and histone acetylation regulate the loss of competence to inductive signals during early development in Xenopus laevis.

Developmental Biology · Feb 28, 2020Peer-reviewedDevelopmental Biology