Kathryn E. Wellen

This study shows that BCAAs are sensed differently by mTOR and c-Myc in T cells, governing proliferation independently of catabolism.

This study shows that histone propionylation, influenced by nutrient availability, regulates T cell fate and antitumor immunity.

This study shows mitochondrial copper stabilizes lipoylated TCA cycle proteins, maintaining metabolism and proliferation by supporting lipoylation and TCA cycle function.

This paper identifies ACSS1 as a metabolic driver in lymphomas, showing its role in acetate-to-acetyl-CoA conversion and pyrimidine biosynthesis, and demonstrates that targeting ACSS1 suppresses tumor growth.

This study shows that pancreas-specific BCKDK inhibition accelerates pancreatic cancer while systemic BCKDK inhibition reduces tumor formation.

This study identifies a nuclear branched-chain amino acid catabolism pathway in pancreatic cancer that regulates histone propionylation and gene expression.

This study shows that αKG-mediated carnitine synthesis supports HR proficiency by promoting histone acetylation, which enhances DNA repair.