Author

Laura V. Pinheiro

University of PennsylvaniaORCID 0000-0002-0332-7450Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Adam G. ChatoffiD· 3 shared Kathryn E. WelleniD· 3 shared Mariola M. MarcinkiewicziD· 3 shared Michael NojiiD· 3 shared Nathaniel W. SnyderiD· 3 shared Alison JaccardiD· 2 shared Christina DemetriadouiD· 2 shared Jennifer L Pennise· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersCancer Biology

Adam G. ChatoffORCID

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Author profile →

3 papers

Recent·Most cited

Nutrient-sensitive histone propionylation regulates T cell fate and function

Alison Jaccard, Kelly Rome, Qihua Yang, Shuo Zhang, Noah Ford, Adam G. Chatoff, Tran Ngoc Van Le, Michael Noji, Andrea Andress Huacachino, Stephanie Stransky, Carlos M. Pondevida, Krittin Trihemasava, Laura V. Pinheiro, Sanat Bhadsalve, Eun Kyung Ko, , Kathryn E. Wellen

This study shows that histone propionylation, influenced by nutrient availability, regulates T cell fate and antitumor immunity.

bioRxiv · Oct 6, 2026 · PreprintImmunology

Opposing effects of systemic and pancreas-specific inhibition of BCKDK on pancreatic carcinogenesis

Michael Noji, Christina Demetriadou, Madelyn D. Landis, Jennifer L Pennise, Laura V. Pinheiro, Alison Jaccard, Adam G. Chatoff, Jack M. Drummond, Kevin Guo, Romie Azor, Maggie R. Robertson, Ryo Kawakami, Mariola M. Marcinkiewicz, John W. Tobias, Nathaniel W. Snyder, , Kathryn E. Wellen

This study shows that pancreas-specific BCKDK inhibition accelerates pancreatic cancer while systemic BCKDK inhibition reduces tumor formation.

bioRxiv · Jun 10, 2025 · PreprintCancer Biology

A nuclear branched-chain amino acid catabolism pathway controls histone propionylation in pancreatic cancer

Christina Demetriadou, Michael Noji, Austin L. Good, Erick Mitchell-Velasquez, Sharan Venkatesh, Daniel S. Kantner, Jennifer L Pennise, Pedro Costa‐Pinheiro, Laura V. Pinheiro, Taku Harada, Phuong Trang Nguyen, Adam G. Chatoff, Emily Megill, Claudia Veronica Da Silva Crispim, Mariola M. Marcinkiewicz, , Kathryn E. Wellen

This study identifies a nuclear branched-chain amino acid catabolism pathway in pancreatic cancer that regulates histone propionylation and gene expression.

bioRxiv · Apr 23, 2025 · PreprintCancer Biology