Author

Jacob D. Ellis

Vanderbilt University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:Bayesian inference· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Scott W. HiebertiD· 3 shared Hillary M. LaydeniD· 2 shared Kristy R. StengeliD· 2 shared Monica L. BomberiD· 2 shared Abdülkadir ElmasiD· 1 shared Clare Spielman· 1 shared Hideru Obinata· 1 shared Jing WangiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersGenomics

Scott W. HiebertORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Expression-Driven Genetic Dependency Reveals Targets for Precision Medicine

Abdülkadir Elmas, Hillary M. Layden, Jacob D. Ellis, Luke N. Bartlett, Xian Zhao, Reika Kawabata‐Iwakawa, Hideru Obinata, Scott W. Hiebert, Kuan‐lin Huang

The paper identifies expression-driven genetic dependency targets for precision oncology using a Bayesian approach, revealing new druggable genes and validating their therapeutic potential.

bioRxiv · Oct 17, 2024 · PreprintGenomics

PAX3-FOXO1 coordinates enhancer architecture, eRNA transcription, andRNA polymerase pause release at select gene targets

Susu Zhang, Jing Wang, Qi Liu, William Hayes McDonald, Monica L. Bomber, Hillary M. Layden, Jacob D. Ellis, Scott C. Borinstein, Scott W. Hiebert, Kristy R. Stengel

This study uses a chemical-genetic approach to show that PAX3-FOXO1 regulates enhancer architecture, eRNA transcription, and RNA polymerase pause release at specific gene targets.

Molecular Cell · Nov 16, 2022Peer-reviewedMolecular Biology

Definition of a Small Core Transcriptional Circuit Regulated by AML1-ETO

Kristy R. Stengel, Jacob D. Ellis, Clare Spielman, Monica L. Bomber, Scott W. Hiebert

The paper defines a small core transcriptional circuit regulated by AML1-ETO using CRISPR-based degradation and transcriptomic analysis.

Molecular Cell · Dec 30, 2020Peer-reviewedGenomics