Kristy R. Stengel

Systematic functional dissection of germline noncoding risk variants impacting clonal hematopoiesis

The paper identifies non-coding variants associated with clonal hematopoiesis and demonstrates their regulatory impact on gene expression and clonal expansion.

The Power of Three: Dynactin associates with three dyneins under load for greater force production

The paper shows that mechanical tension recruits a third dynein motor to DDB complexes, enhancing force production and stability under load.

Histone Deacetylases (HDACs) maintain expression of the pluripotent gene network via recruitment of RNA polymerase II to coding and non-coding loci

The paper shows HDACs maintain pluripotency by regulating RNA polymerase II recruitment to enhancer regions through histone acetylation and BRD4 interactions.

PAX3-FOXO1 coordinates enhancer architecture, eRNA transcription, andRNA polymerase pause release at select gene targets

This study uses a chemical-genetic approach to show that PAX3-FOXO1 regulates enhancer architecture, eRNA transcription, and RNA polymerase pause release at specific gene targets.

Definition of a Small Core Transcriptional Circuit Regulated by AML1-ETO

The paper defines a small core transcriptional circuit regulated by AML1-ETO using CRISPR-based degradation and transcriptomic analysis.

Mtg16-dependent repression of E protein activity is required for early lymphopoiesis

The paper shows that MTG16-dependent repression of E protein activity is essential for lymphopoiesis but not myelopoiesis or stem cell functions, using mouse models and functional assays.