Author

Lauren A. Hinkel

Rutgers, The State University of New JerseyORCID 0000-0001-9363-9628Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Kristin C. Schutz· 2 shared Matthew J. WargoiD· 2 shared Pauline A DiGianivittorioiD· 2 shared Eric A. KleiniD· 1 shared Jacob R. Mackinder· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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2 shared papersMicrobiology

Kristin C. Schutz

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintMar 27, 2025

Sphingosylphosphorylcholine (SPC) is a substrate for the Pseudomonas aeruginosa phospholipase C/sphingomyelinase, PlcH

Pauline A DiGianivittorio, Kristin C. Schutz, Lauren A. Hinkel, Matthew J. Wargo

This paper shows that PlcH and C. perfringens alpha toxin hydrolyze sphingosylphosphorylcholine (SPC), a signaling sphingolipid, which may be a common target for phosphocholine-specific phospholipases during infection.

DOI 10.1101/2025.03.27.645745

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

MicrobiologyMicrobiologyPeer-reviewedJan 10, 2025

The Pseudomonas aeruginosa sphBC genes are important for growth in the presence of sphingosine by promoting sphingosine metabolism

Pauline DiGianivittorio, Lauren A. Hinkel, Jacob R. Mackinder…·Matthew J. Wargo

This study shows that Pseudomonas aeruginosa uses the sphBC genes to metabolize sphingosine, reducing its inhibitory effects on bacterial growth.

3 citations

experimental assay

𝕏 PostBluesky