Temporally discordant chromatin accessibility and DNA demethylation define short and long-term enhancer regulation during cell fate specification
Lindsey N. Guerin, Timothy J. Scott, Jacqueline A. Yap, Annelie Johansson, Fabio Puddu, Tom Charlesworth, Yilin Yang, Alan J. Simmons, Ken S. Lau, Rebecca A. Ihrie, Emily C. Hodges
The paper shows that chromatin accessibility and DNA demethylation occur at different times during enhancer regulation, with methylation states predicting chromatin dynamics using machine learning.
Cell Reports · May 1, 2025Peer-reviewedGenomics