Author

Timothy J. Scott

Vanderbilt University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 3 Organism:human· 3 Research Focus:gene regulatory network inference· 2 Research Focus:GWAS / association mapping· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Emily C. HodgesiD· 3 shared Adam X. MirandaiD· 1 shared Alan J. SimmonsiD· 1 shared Alvin C. PowersiD· 1 shared Annelie JohanssoniD· 1 shared Elizabeth DoransiD· 1 shared Evonne McArthuriD· 1 shared Fabio PudduiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersGenomics

Emily C. HodgesORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Islet-specific DNA hypomethylation identifies gene enhancer loci driving Type 2 Diabetes risk

Verda E. Miranda, Timothy J. Scott, Elizabeth Dorans, Shaojun Mei, Adam X. Miranda, Alvin C. Powers, Lea Karatheodoris Davis, Marcela Briššová, Emily C. Hodges

The paper identifies islet-specific DNA hypomethylated regions linked to T2D risk by integrating DNA methylation data with GWAS and EHR data.

medRxiv · Sep 9, 2025 · PreprintGenetic & Genomic Medicine

Temporally discordant chromatin accessibility and DNA demethylation define short and long-term enhancer regulation during cell fate specification

Lindsey N. Guerin, Timothy J. Scott, Jacqueline A. Yap, Annelie Johansson, Fabio Puddu, Tom Charlesworth, Yilin Yang, Alan J. Simmons, Ken S. Lau, Rebecca A. Ihrie, Emily C. Hodges

The paper shows that chromatin accessibility and DNA demethylation occur at different times during enhancer regulation, with methylation states predicting chromatin dynamics using machine learning.

Cell Reports · May 1, 2025Peer-reviewedGenomics

Cross-tissue patterns of DNA hypomethylation reveal genetically distinct histories of cell development

Timothy J. Scott, Tyler J. Hansen, Evonne McArthur, Emily C. Hodges

The paper identifies DNA hypomethylated regions (HMRs) across human cell types and developmental stages, showing their role in gene regulation and trait heritability.

BMC Genomics · Oct 19, 2023Peer-reviewedGenomics