Genome-Wide CRISPRi Screening Identifies XPO5 as a Regulator of B Cell Mutation and Fitness
Tylar Kirch, Zachary D. Miller, Jacob S. Dearborn, William G Dowell, Sylvester Languon, Hana Paculová, Jade H Cleary, Seth E. Frietze, Kalev Freeman, Devdoot S. Majumdar
This study identifies XPO5 as a regulator of B cell receptor surface expression through a genome-wide CRISPRi screen, showing its role in balancing mutagenesis and DNA repair during somatic hypermutation.
bioRxiv · Apr 24, 2026 · PreprintCell Biology