Kalev Freeman

This study shows that endothelial calcium signaling spreads widely during vascular injury, but phosphatidylserine externalization remains localized, revealing spatial uncoupling between calcium signaling and phospholipid scrambling.

The paper investigates PABPC1's role in alternative polyadenylation during B cell development, finding it primarily shortens and downregulates its targets in a context-dependent manner.

This study identifies XPO5 as a regulator of B cell receptor surface expression through a genome-wide CRISPRi screen, showing its role in balancing mutagenesis and DNA repair during somatic hypermutation.

The paper investigates how extracellular Ca2+ shields endothelial cells from histone-induced injury and enables membrane repair through direct interaction with histones and membrane phospholipids.

This study shows that pathogenic tau peptides reduce endothelial calcium signaling and vasodilation in brain microvessels, impairing cerebral blood flow.