Loss of cell junctional components and matrix alterations drive cell desquamation and fibrotic changes in Idiopathic Pulmonary Fibrosis
Rachana R. Chandran, Preethi Vijayaraj, Rolando García-Milian, Jade King, Kristen Castillo, Liang Chen, Yu Mi Kwon, Sarai William, Tammy M. Rickabaugh, Justin Langerman, Woosuk Choi, Chandani Sen, Jacelyn E. Peabody Lever, Qian Li, Nikoleta Pavelková, , Brigitte N. Gomperts
The study identifies loss of cell junctions and matrix dysregulation as drivers of epithelial desquamation and fibrosis in IPF distal bronchioles.
bioRxiv · Jun 17, 2024 · PreprintPathology