Yu Mi Kwon

This study maps age-related cellular senescence in human lymph nodes, identifying senescence markers and spatial shifts in germinal center B cells.

This study evaluates chemical decrosslinking to improve proteome coverage in FFPE tissues, finding that 3,4-diaminobenzoic acid enhances precursor identifications in pancreatic samples.

This paper develops a high-throughput single-cell proteomic method for PBMCs, achieving 660 cells per day with 750 protein identifications per cell and identifying low-frequency cell types.

This paper introduces multi-tiered Dicers for microdissection, achieving better protein preservation and higher peptide/protein yield compared to LCM at 10-20 micron resolution.

The paper uses single-islet proteomics to analyze pseudo-temporal immune responses and beta-cell dysfunction in stage 1 T1D, identifying key pathways involved in islet dysfunction.

This study benchmarks label-free and TMT-MS2 methods for spatial proteome mapping, showing label-free provides deeper coverage and higher dynamic range, while TMT-MS2 offers faster throughput.

The study identifies loss of cell junctions and matrix dysregulation as drivers of epithelial desquamation and fibrosis in IPF distal bronchioles.