Author

Liang Chen

Capital Institute of PediatricsORCID 0000-0002-9102-8193Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Liang Chen20 papers · Pacific Northwest National Laboratory

Biology Disciplines

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Neuroscience· 3 Genetic & Genomic Medicine· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Allan Micheil InnesiD· 1 shared Ana S.A. CoheniD· 1 shared Benjamin CognéiD· 1 shared Bernt PoppiD· 1 shared Bin LuiD· 1 shared Bonnie R. SullivaniD· 1 shared Boris KereniD· 1 shared Brigitte N. GompertsiD· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Allan Micheil InnesORCID

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Author profile →

5 papers

Recent·Most cited

Loss of cell junctional components and matrix alterations drive cell desquamation and fibrotic changes in Idiopathic Pulmonary Fibrosis

Rachana R. Chandran, Preethi Vijayaraj, Rolando García-Milian, Jade King, Kristen Castillo, Liang Chen, Yu Mi Kwon, Sarai William, Tammy M. Rickabaugh, Justin Langerman, Woosuk Choi, Chandani Sen, Jacelyn E. Peabody Lever, Qian Li, Nikoleta Pavelková, , Brigitte N. Gomperts

The study identifies loss of cell junctions and matrix dysregulation as drivers of epithelial desquamation and fibrosis in IPF distal bronchioles.

bioRxiv · Jun 17, 2024 · PreprintPathology

MARK2 variants cause autism spectrum disorder via the downregulation of WNT/β-catenin signaling pathway

Maolei Gong, Jiayi Li, Yijun Liu, Matheus Vernet Machado Bressan Wilke, Qian Li, Haoran Liu, Liang Chen, Joel A. Morales‐Rosado, Ana S.A. Cohen, Susan Starling Hughes, Bonnie R. Sullivan, Valerie Waddell, Marie‐José H. van den Boogaard, Richard H. van Jaarsveld, Ellen van Binsbergen, , Xiaoli Chen

This study identifies MARK2 variants as a cause of autism spectrum disorder by showing they disrupt the WNT/β-catenin signaling pathway and impair neural development.

medRxiv · Apr 24, 2024 · PreprintGenetic & Genomic Medicine

Cortical ensemble activity discriminates auditory attentional states

Pantong Yao, Jia Shen, Liang Chen, Shaoyu Ge, Qiaojie Xiong

This study shows that auditory cortical activity in mice differs based on attentional states, with attended and ignored conditions showing similar patterns compared to passive hearing.

Molecular Brain · Oct 17, 2019Peer-reviewedNeuroscience

Physiological Significance of R-fMRI Indices: Can Functional Metrics Differentiate Structural Lesions (Brain Tumors)?

Zhen Fan, Xiao Chen, Zengxin Qi, Le Li, Bin Lu, Conglin Jiang, Renqing Zhu, Chao‐Gan Yan, Liang Chen

This study evaluates whether R-fMRI indices can differentiate brain tumors from normal tissue and finds that ALFF and VMHC, with Z-standardization, are effective in this task.

NeuroImage Clinical · Jan 1, 2019Peer-reviewedNeuroscience

Neural code uses self-information principle to organize the brain’s universal cell-assembly coding

Meng Li, Kun Xie, Hui Kuang, Jun Liu, Deheng Wang, Grace E. Fox, Zhifeng Shi, Liang Chen, Zhao Fang, Ying Qing Mao, Joe Z. Tsien

The paper introduces a theory of neural coding based on self-information principles and demonstrates its application in identifying cell-assembly patterns across various brain activities.

Cerebral Cortex · Apr 13, 2018Peer-reviewedNeuroscience