AKAP1 regulates mitochondrial and synaptic homeostasis to enable neuroprotection and repair in retinal ganglion cell degeneration
Tonking Bastola, Keun-Young Kim, Ziyao Shen, Guy A Perkins, Muna Poudel, Veronica Gomez, Yoonjin Lim, Hyejeong Choi, Jae Yon Won, Soo‐Ho Choi, Mark H. Ellisman, Robert Neal Weinreb, Won‐Kyu Ju
The paper identifies AKAP1 as a critical regulator of mitochondrial and synaptic homeostasis in glaucoma, showing its role in neuroprotection and axon regeneration through gene therapy in mouse models.
bioRxiv · Nov 24, 2025 · PreprintNeuroscience