Tumor Cells Enriched for Interferon and Inflammatory Programs Pre-Exist in High Grade Serous Ovarian Cancer and are Proportionately Significantly Increased Post Chemotherapy
Boris J. N. Winterhoff, Nomeda Girnius, Muyi Liu, Jaeyoung Kang, Mihir Shetty, M. Angie Martinez-Gakidis, Weiyi Xu, Mayura Thomas, Linna Lahmadi, Aylin Z. Henstridge, Pilar Baldominos, Shobhana Talukdar, Zenas Chang, Jordan N. Mattson, Morgan Gruner, , Joan S. Brugge
The paper identifies pre-existing tumor cells with interferon and inflammatory programs in HGSOC that increase after chemotherapy, suggesting a therapeutic window for intervention.
bioRxiv · Jun 24, 2025 · PreprintCancer Biology