AMPK reinforces mitochondrial metabolism and suppresses pathological remodeling in Complex V-deficient cardiomyocytes
Esteban Palacios-Contreras, Karen an der Brugge, Jakob Fell, Till Stephan, Hugo Amedei, Christof Lenz, Jelena Pesek, Verena Taudte, Felix Lange, Stefan Jakobs, Samuel Tobias Sossalla, Laura Cecilia Zelarayan, Alfredo Cabrera‐Orefice, Lukas Cyganek, Mario Pávez
This study shows that AMPK activation rescues mitochondrial function and structural remodeling in TMEM70-deficient cardiomyocytes, highlighting a metabolic rescue mechanism in mitochondrial cardiomyopathy.
bioRxiv · Sep 17, 2026 · PreprintCell Biology