Christof Lenz

AMPK reinforces mitochondrial metabolism and suppresses pathological remodeling in Complex V-deficient cardiomyocytes

This study shows that AMPK activation rescues mitochondrial function and structural remodeling in TMEM70-deficient cardiomyocytes, highlighting a metabolic rescue mechanism in mitochondrial cardiomyopathy.

18S rRNA 3’ end cleavage by the phosphorylated endoribonuclease NOB1 is interconnected with early small subunit biogenesis

The paper shows that phosphorylation of NOB1, an endoribonuclease, affects 18S rRNA processing and pre-rRNA levels during small subunit biogenesis.

Regulation of RNA maturation by the family of human G-patch proteins

The paper identifies RNA helicase partners of G-patch proteins and reveals distinct regulatory mechanisms by which they influence mRNA maturation.

Stretched Exponential Modeling Reveals Drug-Specific Kinetics in Human Engineered Skeletal Muscle

This study develops a stretched exponential model to analyze drug-specific contraction kinetics in human engineered skeletal muscle, revealing distinct kinetic signatures not detectable by peak force alone.

Natural aging drives a subclinical cardiovascular phenotype in a non-human primate

This study examines natural cardiovascular aging in non-human primates, finding histological and molecular changes associated with aging, including fibrosis, inflammation, and atherosclerosis.

Profiling the LAM family of contact site tethers provides insights into their regulation and function

The paper profiles the LAM family of contact site tethers to understand their localization and function, revealing unique and shared roles through proximity labeling.

Unbiased complexome profiling and global proteomics analysis reveals mitochondrial impairment and potential changes at the intercalated disk in presymptomatic R14Delta/+ mice hearts

mini-Complexome Profiling (mCP), an FDR-controlled workflow for global targeted detection of protein complexes

The paper introduces mCP, a streamlined workflow for detecting protein complexes with reduced fractionation, and demonstrates its application in analyzing cardiac tissue.

PKCα-dependent interaction of otoferlin and calbindin: evidence for regulation of endocytosis in inner hair cells

The paper identifies PKCα-dependent interactions between otoferlin and calbindin in inner hair cells, suggesting a role in regulating endocytosis through Ca2+-dependent signaling complexes.