Stefan Jakobs

AMPK reinforces mitochondrial metabolism and suppresses pathological remodeling in Complex V-deficient cardiomyocytes

This study shows that AMPK activation rescues mitochondrial function and structural remodeling in TMEM70-deficient cardiomyocytes, highlighting a metabolic rescue mechanism in mitochondrial cardiomyopathy.

Self-blinking dye restores efficient use of nanobodies in single-molecule localization microscopy.

This paper demonstrates that self-blinking dye JF635b improves nanobody performance in single-molecule localization microscopy, enabling reliable imaging across multiple modalities with high precision.

Sarcomere analysis in human cardiomyocytes by computing radial frequency spectra

This paper introduces a computational method to analyze sarcomere properties in human cardiomyocytes using radial frequency spectra, showing its effectiveness in detecting molecular differences in cardiac diseases.

Detergent-free reconstitution of transmembrane proteins in giant liposomes of complex curvature by the Synthetic Membrane Transfer

This paper introduces a detergent-free method to reconstitute transmembrane proteins into GUVs with complex curvature, enabling functional studies of membrane proteins in physiologically relevant geometries.

Super-resolution microscopy of mitochondrial mRNAs

This study uses super-resolution microscopy to visualize mitochondrial mRNAs and their interactions with proteins, revealing dynamic changes in mRNA distribution and structure during apoptosis and in disease.

Mitochondrial inner membrane remodeling as a driving force of organelle shaping

This study investigates how mitochondrial inner membrane remodeling drives organelle shape changes, linking cristae formation to mitochondrial morphology and function.

Nanobinders for Synaptotagmin 1 enable the analysis of synapticvesicle dynamics in rodent and human models.

The paper introduces NbLumSyt1 nanobinders for analyzing synaptic vesicle dynamics in rodent and human models with improved precision and versatility.

In-situ architecture of the human prohibitin complex

This study determines the molecular organisation of the human prohibitin complex within the mitochondrial inner membrane using structural biology methods.

MultiMatch: Geometry-Informed Colocalization in Multi-Color Super-Resolution Microscopy

MultiMatch analyzes chain-like particle arrangements in multi-color microscopy using optimal transport, outperforming existing methods in recovering chain structures.

Three-dimensional multi-target super-resolution microscopy of cells using Metal-Induced Energy Transfer and DNA-PAINT

This paper introduces MIET-PAINT, a method combining DNA-PAINT and Metal-Induced Energy Transfer to achieve nanometer-scale 3D imaging with high multiplexing capability.

The Positive Switching RSFP Padron2 Enables Live-Cell RESOLFT Nanoscopy Without Sequential Irradiation Steps