Author

Mario Pávez

Justus-Liebig-Universität GießenORCID 0000-0002-3330-9384Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Assay:metabolomics· 1

Frequent Co-Authors

Lukas CyganekiD· 2 shared Alfredo Cabrera‐OreficeiD· 1 shared Arne ZibatiD· 1 shared Axel MunkiD· 1 shared Bernd WollnikiD· 1 shared Carolin Argyriou· 1 shared Christof LenziD· 1 shared Constantin Tilman Schott· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

Lukas CyganekORCID

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2 papers

Recent·Most cited

AMPK reinforces mitochondrial metabolism and suppresses pathological remodeling in Complex V-deficient cardiomyocytes

Esteban Palacios-Contreras, Karen an der Brugge, Jakob Fell, Till Stephan, Hugo Amedei, Christof Lenz, Jelena Pesek, Verena Taudte, Felix Lange, Stefan Jakobs, Samuel Tobias Sossalla, Laura Cecilia Zelarayan, Alfredo Cabrera‐Orefice, Lukas Cyganek, Mario Pávez

This study shows that AMPK activation rescues mitochondrial function and structural remodeling in TMEM70-deficient cardiomyocytes, highlighting a metabolic rescue mechanism in mitochondrial cardiomyopathy.

bioRxiv · Sep 17, 2026 · PreprintCell Biology

Distinct mitochondrial DNA single-nucleotide variant signatures in TOP3A-deficient cardiomyocytes

Marianne Gaubert, Halima Alachram, Ipek Ilgin Gönenç, Iñigo Domínguez, Carolin Argyriou, Julia Schmidt, Silke Kaulfuß, Mario Pávez, Constantin Tilman Schott, Axel Munk, Arne Zibat, Lukas Cyganek, Gökhan Yigit, Bernd Wollnik

This study identifies unique mtDNA mutation patterns in TOP3A-deficient cardiomyocytes, linking mtDNA instability to mitochondrial dysfunction in cardiac disease.

bioRxiv · Aug 22, 2026 · PreprintGenetics