Author

James J Collins

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Biology Disciplines

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Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Alejandro ChaveziD· 1 shared Benjamin W Pruitt· 1 shared Brian M Turczyk· 1 shared George M Church· 1 shared Jordan Winston· 1 shared Marcelle Tuttle· 1 shared Michael Tung· 1 shared Rebecca S Shapiro· 1 shared

Activity by Year

2018-2018 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperSynthetic Biology

Alejandro ChavezORCID

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1 paper

Recent·Most cited

Precise Cas9 targeting enables genomic mutation prevention

Alejandro Chavez, Benjamin W Pruitt, Marcelle Tuttle, Rebecca S Shapiro, Ryan J Cecchi, Jordan Winston, Brian M Turczyk, Michael Tung, James J Collins, George M Church

This paper introduces a method to tune guide RNA for precise Cas9 targeting, preventing mutations in engineered organisms and demonstrating scalability and robustness across Cas9 variants and environments.

Proceedings of the National Academy of Sciences · Mar 19, 2018Peer-reviewedSynthetic Biology