Author

Marcelle Tuttle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Alejandro ChaveziD· 2 shared Benjamin W Pruitt· 2 shared George M Church· 2 shared Brian M Turczyk· 1 shared Christopher D Guzman· 1 shared Collins J Collins· 1 shared Daniel J. Wiegand· 1 shared Dimtry Ter-Ovanesyan· 1 shared

Activity by Year

2014-2018 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersSynthetic Biology

Alejandro ChavezORCID

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2 papers

Recent·Most cited

Precise Cas9 targeting enables genomic mutation prevention

Alejandro Chavez, Benjamin W Pruitt, Marcelle Tuttle, Rebecca S Shapiro, Ryan J Cecchi, Jordan Winston, Brian M Turczyk, Michael Tung, James J Collins, George M Church

This paper introduces a method to tune guide RNA for precise Cas9 targeting, preventing mutations in engineered organisms and demonstrating scalability and robustness across Cas9 variants and environments.

Proceedings of the National Academy of Sciences · Mar 19, 2018Peer-reviewedSynthetic Biology

Highly-efficient Cas9-mediated transcriptional programming

Alejandro Chavez, Jonathan Scheiman, Suhani Vora, Benjamin W Pruitt, Marcelle Tuttle, Eswar Iyer, Samira Kiani, Christopher D Guzman, Daniel J. Wiegand, Dimtry Ter-Ovanesyan, Jonathan L Braff, Noah Davidsohn, Ron Weiss, John Aach, Collins J Collins, George M Church

This study develops a highly efficient Cas9-based transcriptional activator, VPR-Cas9, capable of activating multiple genes and promoting neuronal differentiation from iPSCs.

bioRxiv · Dec 20, 2014Synthetic Biology