Author

Shangming Tang

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Neil HunteriD· 2 shared Aakrosh RataniD· 1 shared Anna R. Bartosik· 1 shared Caixian ZhouiD· 1 shared Christie Hall· 1 shared Christopher M. MaiD· 1 shared Dhananjaya S. KulkarniiD· 1 shared Emerald Nguyen· 1 shared

Activity by Year

2018-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCell Biology

Neil HunterORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Protection of double-Holliday junctions ensures crossing over during meiosis

Shangming Tang, Sara Hariri, Regina Rillo-Bohn, John E. McCarthy, Jennifer Koo, Mohammad S. Pourhosseinzadeh, Emerald Nguyen, Natalie Liu, Christopher M. Ma, Hanyu Lu, Monica M. Lee, Neil Hunter

This study shows that synaptonemal complex components protect double-Holliday junctions to ensure crossover recombination during meiosis.

Nature · Sep 24, 2025Peer-reviewedCell Biology

Fork Reversal Safeguards Epigenetic Inheritance during DNA Replication Under Stress

Qiong Wu, Caixian Zhou, Yue Dou, Nadia I. Martin, Maria Gwit, Tae-Hee Lee, Mark Hedglin, Rosea Chen, Ke Zhu, Tianpeng Zhang, Shangming Tang, Tian Zhang, Tyler Weaver, Wenpeng Liu

This study shows that replication fork reversal is essential for maintaining epigenetic inheritance under replication stress by preventing nucleosome loss and ensuring histone transfer.

bioRxiv · Sep 21, 2025 · PreprintBiochemistry

Loss of DHX36/G4R1, a G4 resolvase, drives genome instability and regulates innate immune gene expression in cancer cells

Anna R. Bartosik, Pei‐Chi Hou, Shangming Tang, James P. Vaughn, Philip J. Smaldino, Aakrosh Ratan, Marty W. Mayo, Yuh‐Hwa Wang

This study shows that loss of DHX36/G4R1 increases genome instability and innate immune gene expression in cancer cells, correlating with improved survival in B-cell acute lymphoblastic leukemia.

Nucleic Acids Research · Jun 14, 2025Peer-reviewedMolecular Biology

The crossover function of MutSγ is activated via Cdc7-dependent stabilization of Msh4

Wei He, H. B. D. Prasada Rao, Shangming Tang, Nikhil R. Bhagwat, Dhananjaya S. Kulkarni, Maria A.W. Chang, Christie Hall, Lepakshi Singh, Xiangyu Chen, Nancy M. Hollingsworth, Petr Ćejka, Neil Hunter

This study shows that MutSγ activation during meiosis depends on Cdc7-mediated phosphorylation of Msh4, stabilizing the complex and enabling crossover formation.

bioRxiv · Aug 27, 2018 · PreprintGenetics