Author

James Pratt

University of Colorado Boulder

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Kathleen L. McCanniD· 3 shared Roy ParkeriD· 3 shared Evan LesteriD· 2 shared Jeff Kuo· 2 shared Meaghan Van AlstyneiD· 2 shared Carolyn J. DeckeriD· 1 shared Li Yi ChengiD· 1 shared Spoorthy Reddy· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 30 mutual co-author links

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3 shared papersNeuroscience

Kathleen L. McCannORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Nuclear tau aggregates inhibit RNA export and form by secondary seeding from cytosolic tau aggregates.

Carolyn J. Decker, Kathleen L. McCann, Evan Lester, James Pratt, Meaghan Van Alstyne, Yuchen Wang, Roy Parker

bioRxiv · Feb 18, 2026 · PreprintNeuroscience

Polyserine-tau interactions modulate tau fibrilization

James Pratt, Kathleen L. McCann, Jeff Kuo, Roy Parker

This study shows polyserine domains self-assemble and interact with tau to form sites of aggregation, accelerating tau fibrilization in vitro.

Journal of Biological Chemistry · Jul 25, 2025Peer-reviewedBiochemistry

Cytosolic condensates enriched in polyserine repeats are preferred sites of tau fiber propagation

Evan Lester, Meaghan Van Alstyne, Kathleen L. McCann, Spoorthy Reddy, Li Yi Cheng, Jeff Kuo, James Pratt, Roy Parker

The paper shows polyserine repeats in SRRM2 and PNN recruit to tau aggregates and promote tau fiber propagation in cytoplasmic condensates.

bioRxiv · Sep 22, 2022 · PreprintNeuroscience

James Pratt · henhao