Jeff Kuo

Polyserine-tau interactions modulate tau fibrilization

This study shows polyserine domains self-assemble and interact with tau to form sites of aggregation, accelerating tau fibrilization in vitro.

Cytosolic condensates enriched in polyserine repeats are preferred sites of tau fiber propagation

The paper shows polyserine repeats in SRRM2 and PNN recruit to tau aggregates and promote tau fiber propagation in cytoplasmic condensates.