Cytosolic condensates enriched in polyserine repeats are preferred sites of tau fiber propagation
Evan Lester, Meaghan Van Alstyne, Kathleen L. McCann, Spoorthy Reddy, Li Yi Cheng, Jeff Kuo, James Pratt, Roy Parker
The paper shows polyserine repeats in SRRM2 and PNN recruit to tau aggregates and promote tau fiber propagation in cytoplasmic condensates.
bioRxiv · Sep 22, 2022 · PreprintNeuroscience