NeurosciencebioRxivPreprint
Nuclear tau aggregates inhibit RNA export and form by secondary seeding from cytosolic tau aggregates.
Carolyn J. Decker, Kathleen L. McCann, Evan Lester…·Roy Parker
1 citation
Author
Kathleen L. McCann
Howard Hughes Medical InstituteORCID 0000-0002-7144-4851Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2022-2026 · peak 1/yrCo-Author Collaboration Network
9 top collaborators · 30 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship3 papers
Recent·Most cited
- BiochemistryJournal of Biological ChemistryPeer-reviewed
Polyserine-tau interactions modulate tau fibrilization
James Pratt, Kathleen L. McCann, Jeff Kuo, Roy Parker
This study shows polyserine domains self-assemble and interact with tau to form sites of aggregation, accelerating tau fibrilization in vitro.
- NeurosciencebioRxivPreprint
Cytosolic condensates enriched in polyserine repeats are preferred sites of tau fiber propagation
Evan Lester, Meaghan Van Alstyne, Kathleen L. McCann…·Roy Parker
The paper shows polyserine repeats in SRRM2 and PNN recruit to tau aggregates and promote tau fiber propagation in cytoplasmic condensates.
DOI 10.1101/2022.09.22.509111